Innovation-driven strategies have become the core of national development during the transition period in China, where the research into ethical issues such as the dislocation of accountability structures and the emergence of value conflicts is insufficient. From the perspective of responsible innovation, this paper firstly introduced the methods of socio-technical value analyses (CTA and VSD) to determine value agents, whereby constructed the proxy accountability structures of value conflicts. Furthermore, the transformation chain of value conflicts was brought up in the light of technological niche theory. According to the main scenarios of value conflicts, we divided the transformation processes into four stages (the early warning, the upgrading, the adjustment and the stabilization) and indicated different characteristics based on certain concrete cases. Finally, the socio-technical value analyses were incorporated with the transformation chain of value conflicts, aiming at developing a multi-process dynamic framework of responsible innovation.