Based on the perspective of scientific knowledge map, the 2855 literatures’ bibliography published in Research Policy from 1974 to 2016, which studied the science and technology policy, were used as data samples to obtain the institutional, national and regional distribution of the international scientific and technological policy research. Through the analysis of high-frequency keywords to determine the hot areas of international science and technology policy research, by detecting the keywords which had significant changing trendence to determine the forefront of the field and development trends in the field of international science and technology policy research, this paper analyzed the evolution process of international research on science and technology policy. The research shows that the international research on science and technology policy has changed obviously over the past 42 years, which is mainly reflected in the following aspects: Firstly, the research scope is developed from the sporadic "science and technology policy" to the current scientific and standardized research on " science of science policy". Secondly, the research perspective is from the macro-research at the national level to the micro-tilt, and thirdly the research hotspot is diversely expanded from knowledge management, national innovation system and so on to open innovation, triple helix innovation, team knowledge creation and so on. At the same time, it is found that the international research on science and technology policy was mainly influenced by the theory of national innovation system of Nelson and Porter's national competitive advantage at the early stage, and is mainly influenced by open innovation theory and triple helix innovation theory at present. This paper provides a new reference and basis for a more comprehensive understanding of the development and evolution process of international research on science and technology policy, and for grasping the knowledge base, research hotspot and development direction in this field.